Primary and secondary bile acids in stool
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Plot only those metabolites that had at least one comparison with a significant q-value.
| comparison | BIOCHEMICAL | .y. | group1 | group2 | n1 | n2 | statistic | df | p | p.adj | p.adj.signif | q.value | q.value.sign | FoldChange | log2FoldChange | diffexpressed | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 9 | AH_HDC | dehydrolithocholate | log10_value | HDC | AH | 20 | 29 | 5.639 | 42.385 | 0.000 | 0.000 | **** | 0.000 | TRUE | 0.119 | -3.070 | DOWN |
| 10 | AH_HDC | deoxycholate | log10_value | HDC | AH | 20 | 29 | 7.129 | 46.979 | 0.000 | 0.000 | **** | 0.000 | TRUE | 0.070 | -3.843 | DOWN |
| 12 | AH_HDC | glycochenodeoxycholate glucuronide (1) | log10_value | HDC | AH | 20 | 29 | -2.784 | 28.467 | 0.009 | 0.049 |
|
0.032 | TRUE | 14.504 | 3.858 | UP |
| 13 | AH_HDC | glycochenodeoxycholate sulfate | log10_value | HDC | AH | 20 | 29 | -2.882 | 33.313 | 0.007 | 0.042 |
|
0.027 | TRUE | 309.187 | 8.272 | UP |
| 15 | AH_HDC | glycocholate glucuronide (1) | log10_value | HDC | AH | 20 | 29 | -2.374 | 28.000 | 0.025 | 0.119 | ns | 0.077 | TRUE | 8.515 | 3.090 | NO |
| 16 | AH_HDC | glycocholate sulfate | log10_value | HDC | AH | 20 | 29 | -2.328 | 28.000 | 0.027 | 0.119 | ns | 0.077 | TRUE | 24.512 | 4.615 | NO |
| 17 | AH_HDC | glycocholenate sulfate* | log10_value | HDC | AH | 20 | 29 | -3.061 | 45.261 | 0.004 | 0.029 |
|
0.019 | TRUE | 13.998 | 3.807 | UP |
| 18 | AH_HDC | glycodeoxycholate | log10_value | HDC | AH | 20 | 29 | 6.127 | 23.891 | 0.000 | 0.000 | **** | 0.000 | TRUE | 0.037 | -4.765 | DOWN |
| 20 | AH_HDC | glycolithocholate | log10_value | HDC | AH | 20 | 29 | 2.391 | 19.235 | 0.027 | 0.119 | ns | 0.077 | TRUE | 0.466 | -1.101 | NO |
| 23 | AH_HDC | isoursodeoxycholate | log10_value | HDC | AH | 20 | 29 | 4.089 | 46.887 | 0.000 | 0.002 | ** | 0.001 | TRUE | 0.254 | -1.974 | DOWN |
| 24 | AH_HDC | lithocholate | log10_value | HDC | AH | 20 | 29 | 7.480 | 41.242 | 0.000 | 0.000 | **** | 0.000 | TRUE | 0.168 | -2.577 | DOWN |
| 25 | AH_HDC | taurochenodeoxycholate | log10_value | HDC | AH | 20 | 29 | -3.141 | 46.354 | 0.003 | 0.028 |
|
0.018 | TRUE | 7.829 | 2.969 | UP |
| 27 | AH_HDC | taurocholenate sulfate | log10_value | HDC | AH | 20 | 29 | -3.720 | 45.640 | 0.001 | 0.006 | ** | 0.004 | TRUE | 21.308 | 4.413 | UP |
| 28 | AH_HDC | taurodeoxycholate | log10_value | HDC | AH | 20 | 29 | 2.966 | 23.718 | 0.007 | 0.042 |
|
0.027 | TRUE | 0.115 | -3.114 | DOWN |
| 31 | AH_HDC | ursocholate | log10_value | HDC | AH | 20 | 29 | 2.216 | 46.868 | 0.032 | 0.132 | ns | 0.085 | TRUE | 0.382 | -1.388 | NO |
| 32 | AH_HDC | ursodeoxycholate | log10_value | HDC | AH | 20 | 29 | 2.988 | 46.904 | 0.004 | 0.029 |
|
0.019 | TRUE | 0.352 | -1.506 | DOWN |
| 42 | SAH_MAH | dehydrolithocholate | log10_value | MAH | SAH | 8 | 21 | 0.688 | 13.199 | 0.503 | 0.745 | ns | 0.481 | FALSE | 2.370 | 1.245 | NO |
| 43 | SAH_MAH | deoxycholate | log10_value | MAH | SAH | 8 | 21 | 1.595 | 11.056 | 0.139 | 0.417 | ns | 0.269 | FALSE | 0.153 | -2.709 | NO |
| 45 | SAH_MAH | glycochenodeoxycholate glucuronide (1) | log10_value | MAH | SAH | 8 | 21 | -0.345 | 13.031 | 0.736 | 0.836 | ns | 0.540 | FALSE | 2.305 | 1.205 | NO |
| 46 | SAH_MAH | glycochenodeoxycholate sulfate | log10_value | MAH | SAH | 8 | 21 | 0.399 | 11.736 | 0.697 | 0.836 | ns | 0.540 | FALSE | 4.014 | 2.005 | NO |
| 48 | SAH_MAH | glycocholate glucuronide (1) | log10_value | MAH | SAH | 8 | 21 | -0.122 | 14.571 | 0.905 | 0.963 | ns | 0.622 | FALSE | 2.586 | 1.371 | NO |
| 49 | SAH_MAH | glycocholate sulfate | log10_value | MAH | SAH | 8 | 21 | 0.002 | 10.978 | 0.998 | 0.998 | ns | 0.645 | FALSE | 1.388 | 0.473 | NO |
| 50 | SAH_MAH | glycocholenate sulfate* | log10_value | MAH | SAH | 8 | 21 | 0.332 | 10.153 | 0.747 | 0.836 | ns | 0.540 | FALSE | 0.324 | -1.625 | NO |
| 51 | SAH_MAH | glycodeoxycholate | log10_value | MAH | SAH | 8 | 21 | 1.425 | 7.761 | 0.193 | 0.464 | ns | 0.300 | FALSE | 0.306 | -1.709 | NO |
| 53 | SAH_MAH | glycolithocholate | log10_value | MAH | SAH | 8 | 21 | -1.196 | 20.000 | 0.246 | 0.494 | ns | 0.319 | FALSE | 1.025 | 0.035 | NO |
| 56 | SAH_MAH | isoursodeoxycholate | log10_value | MAH | SAH | 8 | 21 | 1.528 | 11.987 | 0.153 | 0.439 | ns | 0.284 | FALSE | 0.449 | -1.156 | NO |
| 57 | SAH_MAH | lithocholate | log10_value | MAH | SAH | 8 | 21 | 1.015 | 11.913 | 0.330 | 0.605 | ns | 0.391 | FALSE | 0.577 | -0.793 | NO |
| 58 | SAH_MAH | taurochenodeoxycholate | log10_value | MAH | SAH | 8 | 21 | -0.681 | 12.788 | 0.508 | 0.745 | ns | 0.481 | FALSE | 2.964 | 1.567 | NO |
| 60 | SAH_MAH | taurocholenate sulfate | log10_value | MAH | SAH | 8 | 21 | -0.067 | 9.459 | 0.948 | 0.978 | ns | 0.632 | FALSE | 0.211 | -2.242 | NO |
| 61 | SAH_MAH | taurodeoxycholate | log10_value | MAH | SAH | 8 | 21 | 0.906 | 8.867 | 0.389 | 0.658 | ns | 0.425 | FALSE | 0.582 | -0.782 | NO |
| 64 | SAH_MAH | ursocholate | log10_value | MAH | SAH | 8 | 21 | 1.921 | 12.045 | 0.079 | 0.274 | ns | 0.177 | FALSE | 0.260 | -1.945 | NO |
| 65 | SAH_MAH | ursodeoxycholate | log10_value | MAH | SAH | 8 | 21 | 1.365 | 11.010 | 0.200 | 0.464 | ns | 0.300 | FALSE | 0.361 | -1.472 | NO |
Kruskal-Wallis tests on all metabolites to identify which are significant
| ID | BIOCHEMICAL | KW.pvalue | q.value | q.value.sign | Primary_Secondary | Conj_Unconj | Conj_type | Comp12_OH | Comp_12-OH_Fig1_2 | Dihydroxy_Trihydroxy | Comp_7-dehydroxy | Comp_7-dehydro_Fig_1_2 | Keto | Epimer | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | M_2715 | taurochenodeoxycholate | 0.010 | 0.011 | TRUE | P | C | T | n12 | 2 | 2 | n7 | 1 | n | n |
| 10 | M_2727 | glycocholate glucuronide (1) | 0.041 | 0.028 | TRUE | P | C | G/Glu | 12 | 1 | 2 | n7 | 1 | n | n |
| 11 | M_2728 | glycocholate sulfate | 0.039 | 0.027 | TRUE | P | C | G/S | 12 | 1 | 2 | n7 | 1 | n | n |
| 12 | M_2729 | deoxycholate | 0.000 | 0.000 | TRUE | S | UC | 0 | 12 | 1 | 2 | 7 | 2 | n | n |
| 13 | M_2731 | glycodeoxycholate | 0.000 | 0.000 | TRUE | S | C | G | 12 | 1 | 2 | 7 | 2 | n | n |
| 14 | M_2732 | taurodeoxycholate | 0.002 | 0.004 | TRUE | S | C | T | 12 | 1 | 2 | 7 | 2 | n | n |
| 15 | M_2734 | lithocholate | 0.000 | 0.000 | TRUE | S | UC | 0 | n12 | 2 | 1 | 7 | 2 | n | n |
| 16 | M_2736 | glycolithocholate | 0.013 | 0.012 | TRUE | S | C | G | n12 | 2 | 1 | 7 | 2 | n | n |
| 19 | M_2741 | ursodeoxycholate | 0.010 | 0.011 | TRUE | S | UC | 0 | n12 | 2 | 2 (1b) | n7 (b) | N/A | n | y |
| 20 | M_2742 | isoursodeoxycholate | 0.002 | 0.004 | TRUE | S | UC | 0 | n12 | 2 | 2 (2b) | n7 (b) | N/A | n | y |
| 23 | M_2745 | dehydrolithocholate | 0.000 | 0.001 | TRUE | S | UC | 0 | n12 | 2 | 0 | 7 | 2 | y | n |
| 28 | M_2760 | glycocholenate sulfate* | 0.033 | 0.024 | TRUE | O | C | G/S | 12 | 1 | 2 | n7 | 1 | n | n |
| 29 | M_2761 | taurocholenate sulfate | 0.006 | 0.007 | TRUE | O | C | T/S | 12 | 1 | 2 | n7 | 1 | n | n |
| 32 | M_2767 | ursodeoxycholate sulfate (1) | 0.034 | 0.024 | TRUE | S | C | S | n12 | 2 | 1 (1b) | n7 (b) | N/A | n | y |
| 33 | M_2770 | ursocholate | 0.014 | 0.013 | TRUE | S | UC | 0 | 12 | 1 | 3 (2b) | n7 (b) | N/A | n | y |